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When it comes to most people the word design in relation to web design is thought about a lot in terms of the creative side to the site. In other cases, it is referred to as the ways in which the site functions and how it is designed. Companies in Boston who have used Boston web design firms to create their sites are at a larger advantage than those who don’t.

Web design firms understand the functionality and ways in which users navigate through a site. It is very important not to allow a visitor to leave because your site was too difficult to understand.

Heart Attack Symptoms

October 6, 2008InfraReDx, Inc. announced today that it has received 510(k) clearance from the U.S. Food and Drug Administration (FDA) to market its catheter-based LipiScan™ Coronary Imaging System. The LipiScan device uses near-infrared spectroscopy to identify lipid core containing plaques of interest in the coronary arteries in patients already undergoing cardiac catheterization. Such plaques, which cannot be detected by commonly-used tests such as a treadmill examination and even coronary angiography, are suspected to be the cause of most sudden cardiac deaths and non-fatal heart attacks.

The availability of this novel tool culminates a decade-long biomedical engineering effort to create an instrument that could perform spectroscopy in the arteries of patients with coronary artery disease. The identification of the chemical composition of coronary plaques is expected to be of value to cardiologists in the selection of medical, stenting or surgical therapy for coronary lesions. The device is also expected to be of value to the pharmaceutical industry as a means to assess the effect of novel anti-atherosclerotic agents on lipid core plaque burden.

“The InfraReDx team is pleased that the LipiScan System has been validated in tissue samples and a clinical study and has been cleared by the FDA for use in patients. We understand the great potential of interventional cardiology and anticipate that this novel tool will assist physicians with the complex decisions they face in the management of patients with coronary artery disease,” says James E. Muller, M.D., cardiologist, co-founder, President and CEO of InfraReDx, Inc.

Dr. Muller noted that the creation of this novel device was greatly aided by the support and expertise of Sanderling Ventures of San Mateo, California. “Robert McNeil, Ph.D., Chairman of the Board of InfraReDx, and Timothy Mills, Ph.D., InfraReDx Board member are managing directors of Sanderling and both have extensive experience in medical device development,” said Dr. Muller. “Sanderling was a seed investor in Advanced Cardiovascular Systems, a company that pioneered development of balloon angioplasty and was acquired by Guidant.”

“While angioplasty and stenting were major advances, stenting has not been capable of preventing heart attacks due to the difficulty in identifying lesions likely to rupture and cause thrombosis. With the development of the LipiScan Coronary Imaging System, Sanderling is again contributing to a major step forward in providing a useful tool with which interventional cardiologists may improve the care of cardiac patients.”

“There is a real unmet medical need to identify lipid core containing plaques of interest in the coronary arteries, which before now we could not do,” says James Goldstein, M.D., Director of Research and Education at William Beaumont Hospital in Royal Oak, Michigan, who is also an investigator in the SPECTACL clinical trial for the device and a consultant for InfraReDx. “The ability to detect lipid core containing plaques of interest may go a long way in providing information to help prevent heart attacks in the near future.”

How the LipiScan Coronary Imaging System Works
Near-infrared (NIR) spectroscopy is commonly used to measure the chemical composition of unknown substances. The LipiScan Coronary Imaging System utilizes advanced optical technology, much of it developed for telecom uses, to deliver and retrieve NIR light from coronary plaques. The light reflected back at different wavelengths is analyzed to detect the chemical composition of the coronary plaques. At the completion of the catheter pullback, the LipiScan console instantly displays the scan results on a “chemogram”, a digital color-coded map of the location and intensity of lipid core containing plaques of interest in the artery. A Lipid Core Burden Index is also reported, which is a measure of the total amount of lipid core containing plaques of interest in the coronary artery. The LipiScan catheter interrogates each artery in less than 2 minutes and does not require the interruption of the flow of blood.

Successful Clinical Trial Results
The SPECTACL clinical trial documented the similarity of near-infrared spectra obtained from 106 patients undergoing coronary angiography compared to spectra obtained in autopsy specimens in which the gold-standard of histology was available. For more information, visit the InfraReDx website at www.infraredx.com.

About InfraReDx, Inc.
InfraReDx, Inc. is a privately-owned medical device company with expertise in near-infrared (NIR) spectroscopic technology and its application to coronary imaging. The company, located in Burlington, MA, was founded in 1998 to meet the unmet medical need for the detection and identification of lipid core containing plaques of interest in the coronary arteries. To meet this medical need, the Company developed The LipiScan Coronary Imaging System, an easy-to-use, catheter-based coronary imaging system that uses near-infrared spectroscopic technology to detect and characterize the composition of coronary artery plaques in patients undergoing catheterization. Funding for the development of the LipiScan System has been provided by a group of over 80 private investors and Sanderling Ventures. A Series C Funding round in 2007 raised $17 million. For more information, visit the InfraReDx website at www.infraredx.com.

For the past decade, a Boston search engine optimization company has been improving clients rank within search engines.  In this economy, companies are looking for the biggest ‘bang for their buck’ when it comes to advertising budgets. The internet is quickly growing as the number one format for marketing campaigns. For this reason alone, it is important to chose a qualified web design and SEO company.

Recognizing the heart attack symptoms :

October 19, 2006

‘Represents a major milestone in our efforts to provide a tool for the assessment of coronary artery disease,’ CEO Muller says

October 19, 2006 — BURLINGTON, MA

InfraReDx today announced that the U. S. Food and Drug Administration recently issued a clearance for the company’s 510(k) application to market its near infrared (NIR) spectroscopic system for examining coronary arteries. “This clearance represents a major milestone in our efforts to provide a tool for the assessment of coronary artery disease,” said Dr. James Muller, the company’s founder, CEO, and president, explaining that it will enable cardiologists to characterize the composition of coronary artery plaques. InfraReDx was founded to bring the benefits of photonic technology to the task of identifying lipid-rich plaques. Although prospective evidence is not currently available, these plaques are suspected to be “vulnerable” to rupture, subsequently leading to thrombosis and a heart attack. If such plaques could be identified in advance – which coronary angiography, the current-standard-of care, is unable to do – there are many potential treatments that could be evaluated.

The InfraReDx intracoronary spectroscopy system is a novel fiber-optic, catheter-based device with a laser light source. The catheter has been designed to perform spectroscopy in the difficult conditions of motion and blood flow presented by coronary arteries.

Noting that the 510(k) clearance was based largely on the results of research involving autopsy specimens, and experience in an initial ten-patient feasibility study, Dr. Muller emphasized that more extensive studies are currently in progress. A pivotal clinical study – called SPECTacl (Spectroscopic Assessment of Coronary Lipid) – is designed to document the ability of the InfraReDx system to identify distinctive near-infrared spectra in patients. To interpret the meaning of the spectra obtained in the SPECTacl study, a parallel study is being conducted on autopsy specimens in which a histologic gold standard is available.

InfraReDx recently closed a $22.3-million round of funding that will enable the company to complete and submit the results of ongoing studies, finalize product development efforts, and begin the process of preparing for a product launch, expected in 2007. The company expects that the first use of its products will involve patients undergoing percutaneous coronary intervention procedures such as stenting, which are performed on approximately two-million individuals per year.

InfraReDx, founded in 1998 and headquartered in Burlington, Massachusetts, is a privately-funded company developing a fiber-optic, catheter-based, near-infrared (NIR) spectroscopy system to detect lipid-rich plaques in the coronary arteries, which are suspected to be vulnerable plaque, the most frequent cause of heart attacks.

If you are a Boston based company, you probably know how competitive companies can be in this city. It is also noticeable that their web sites are equally competitive. In order to find the best possible Boston web design, keep the following things in mind:

Appearance: Make sure the appearance of your site is clean and understandable. Content: Make sure your potential clients get the information they need and the contact information to reach you. Usability: Dont clutter your site with flash design or unnecessary information. Keep it simple and easy to understand.